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Technical insights

Equipment selection, process scale-up and fundamentals.

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Equipment selection

Five questions before selecting microfluidization equipment

Maximum pressure is not enough. Define material, targets, scale, cooling and evaluation first.

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Scale-up

Recording a homogenization process for scale-up

Traceable experiments support scale-up discussions. Record flow, temperature and formulation conditions alongside pressure.

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Fundamentals

Liposome extrusion: pore size and final particle size

Pore size is one process variable. Formulation, temperature and pass count also affect the resulting distribution.

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